{ "version": 1, "generated_at": "2026-10-10T07:05:59.870Z", "source_sha256": "c7ed10050dbd9bd229a591d31b085d2b662d75a0498a307dbc8fea91e1a08e42", "purpose": "在已进入MD的48条六肽中，建议哪些先补充验证。只比较同一母本组，不预测实验Kd。", "colors": { "parent": "#2474d2", "priority": "#0f766e", "caution": "#d97706", "unmarked": "#94a3b8" }, "labels": { "parent": "原五肽", "priority": "优先补充验证", "caution": "有优势，也有疑点", "unmarked": "暂不优先" }, "rules": { "main_metrics": [ "mean_epitope_coverage_fraction", "TIMP2_blockade_occupancy" ], "auxiliary_metric": "bound_like_population", "frontier": "比较本组五肽和12条六肽的全程覆盖率与几何阻断占有率。如果另一条肽两项都不低、至少一项更高，暂不优先标注前一条（即取双指标Pareto前沿）。1e-12只用于避免浮点误差。", "priority": "原轨迹检查PASS；位于上述Pareto前沿；全程覆盖率、几何阻断占有率、bound-like均不低于母本；五段覆盖率与几何阻断均达到母本100 ns整体水平；60–100 ns按帧加权bound-like不低于该六肽全程值。", "caution": "保留在双指标比较中，但没有全部满足绿色条件。逐条写出差在哪里、是否随时间改变。", "unmarked": "双指标比较中已有别的肽表现更高，或轨迹检查不满足要求。本次暂不优先，不等于没有活性。", "limitations": "规则是在看过当前数据后确定的，没有经过实验验证。未合成总分，未做颜色分类的显著性检验。五段来自同一轨迹；RMSD和构象簇比例不参与选色。" }, "methodology_reference": "https://www.nist.gov/publications/best-practices-quantification-uncertainty-and-sampling-quality-molecular-simulations", "families": [ { "parent_seed": "WPHPY", "priority": [], "caution": [ "KWPHPY", "RWPHPY" ], "unmarked": [ "HWPHPY", "QWPHPY", "WGPHPY", "WNPHPY", "WPHKPY", "WPHNPY", "WPHPLY", "WPHRPY", "WPRHPY", "WRPHPY" ] }, { "parent_seed": "EWWFR", "priority": [ "EWWFAR" ], "caution": [ "EWWFRR" ], "unmarked": [ "EWHWFR", "EWKWFR", "EWRWFR", "EWWAFR", "EWWFKR", "EWWFPR", "EWWFRL", "EWWFRQ", "EWWFRS", "EWWYFR" ] }, { "parent_seed": "RNWIR", "priority": [ "RNWWIR", "RYNWIR" ], "caution": [ "TRNWIR" ], "unmarked": [ "RFNWIR", "RNDWIR", "RNIWIR", "RNKWIR", "RNVWIR", "RNWIRT", "RNWIRV", "VRNWIR", "YRNWIR" ] }, { "parent_seed": "IHWRW", "priority": [], "caution": [ "IHWRPW" ], "unmarked": [ "FIHWRW", "IHFWRW", "IHKWRW", "IHWFRW", "IHWKRW", "IHWRAW", "IHWRIW", "IHWRWD", "IHWRWN", "IKHWRW", "IRHWRW" ] } ], "by_sequence": { "WPHPY": { "sequence": "WPHPY", "parent_seed": "WPHPY", "level": "parent", "label": "原五肽", "color": "#2474d2" }, "HWPHPY": { "sequence": "HWPHPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.344490775118524, "blockade": 0.4768092762894842, "bound_like": 0.45221911235505796, "late_bound_like": 0.07546226886556721, "delta_coverage_pp": -7.681213228994116, "delta_blockade_pp": -20.931627349060378, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "20-40ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "KWPHPY", "RWPHPY", "WPHKPY", "WPHRPY" ], "reasons": [ "本组 WPHPY、KWPHPY、RWPHPY、WPHKPY、WPHRPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 34.45%，低于母本的 42.13%", "几何阻断占有率 47.68%，低于母本的 68.61%", "结合样状态占比 45.22%，低于母本的 64.07%", "20-40 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 7.55%，低于全程的 45.22%，需要回看时间变化" ] }, "KWPHPY": { "sequence": "KWPHPY", "parent_seed": "WPHPY", "level": "caution", "label": "有优势，也有疑点", "color": "#d97706", "coverage": 0.38206146112983375, "blockade": 0.9276289484206317, "bound_like": 0.7692922830867653, "late_bound_like": 0.7561219390304847, "delta_coverage_pp": -3.924144627863141, "delta_blockade_pp": 24.15033986405437, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": false, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [], "reasons": [ "覆盖率 38.21%，低于母本的 42.13%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 75.61%，低于全程的 76.93%，需要回看时间变化" ] }, "QWPHPY": { "sequence": "QWPHPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.1765008282401325, "blockade": 0.07317073170731707, "bound_like": 0.04558176729308277, "late_bound_like": 0.051974012993503245, "delta_coverage_pp": -24.480207916833265, "delta_blockade_pp": -61.2954818072771, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "HWPHPY", "KWPHPY", "RWPHPY", "WGPHPY", "WNPHPY", "WPHKPY", "WPHNPY", "WPHPLY", "WPHRPY", "WPRHPY", "WRPHPY" ], "reasons": [ "本组 WPHPY、HWPHPY、KWPHPY、RWPHPY、WGPHPY、WNPHPY、WPHKPY、WPHNPY、WPHPLY、WPHRPY、WPRHPY、WRPHPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 17.65%，低于母本的 42.13%", "几何阻断占有率 7.32%，低于母本的 68.61%", "结合样状态占比 4.56%，低于母本的 64.07%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "RWPHPY": { "sequence": "RWPHPY", "parent_seed": "WPHPY", "level": "caution", "label": "有优势，也有疑点", "color": "#d97706", "coverage": 0.44949163191866115, "blockade": 0.704718112754898, "bound_like": 0.6951219512195121, "late_bound_like": 0.9985007496251874, "delta_coverage_pp": 2.8188724510195993, "delta_blockade_pp": 1.8592562974810045, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns" ], "dominated_by": [], "reasons": [ "0-20 ns、20-40 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "WGPHPY": { "sequence": "WGPHPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.260010281601645, "blockade": 0.259296281487405, "bound_like": 0.18892443022790884, "late_bound_like": 0.23588205897051473, "delta_coverage_pp": -16.129262580682013, "delta_blockade_pp": -42.6829268292683, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "HWPHPY", "KWPHPY", "RWPHPY", "WNPHPY", "WPHKPY", "WPHPLY", "WPHRPY", "WPRHPY" ], "reasons": [ "本组 WPHPY、HWPHPY、KWPHPY、RWPHPY、WNPHPY、WPHKPY、WPHPLY、WPHRPY、WPRHPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 26.00%，低于母本的 42.13%", "几何阻断占有率 25.93%，低于母本的 68.61%", "结合样状态占比 18.89%，低于母本的 64.07%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "WNPHPY": { "sequence": "WNPHPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.29051236648197865, "blockade": 0.4084366253498601, "bound_like": 0.3690523790483807, "late_bound_like": 0.3313343328335832, "delta_coverage_pp": -13.07905409264865, "delta_blockade_pp": -27.768892443022793, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "HWPHPY", "KWPHPY", "RWPHPY", "WPHKPY", "WPHPLY", "WPHRPY" ], "reasons": [ "本组 WPHPY、HWPHPY、KWPHPY、RWPHPY、WPHKPY、WPHPLY、WPHRPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 29.05%，低于母本的 42.13%", "几何阻断占有率 40.84%，低于母本的 68.61%", "结合样状态占比 36.91%，低于母本的 64.07%", "20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 33.13%，低于全程的 36.91%，需要回看时间变化" ] }, "WPHKPY": { "sequence": "WPHKPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.374250299880048, "blockade": 0.6261495401839264, "bound_like": 0.6239504198320672, "late_bound_like": 0.7021489255372314, "delta_coverage_pp": -4.705260752841717, "delta_blockade_pp": -5.997600959616156, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "80-100ns" ], "dominated_by": [ "WPHPY", "KWPHPY", "RWPHPY" ], "reasons": [ "本组 WPHPY、KWPHPY、RWPHPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 37.43%，低于母本的 42.13%", "几何阻断占有率 62.61%，低于母本的 68.61%", "结合样状态占比 62.40%，低于母本的 64.07%", "0-20 ns、20-40 ns、40-60 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "WPHNPY": { "sequence": "WPHNPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.20903067344490772, "blockade": 0.21211515393842462, "bound_like": 0.18512594962015194, "late_bound_like": 0.31084457771114443, "delta_coverage_pp": -21.227223396355743, "delta_blockade_pp": -47.40103958416634, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "HWPHPY", "KWPHPY", "RWPHPY", "WGPHPY", "WNPHPY", "WPHKPY", "WPHPLY", "WPHRPY", "WPRHPY", "WRPHPY" ], "reasons": [ "本组 WPHPY、HWPHPY、KWPHPY、RWPHPY、WGPHPY、WNPHPY、WPHKPY、WPHPLY、WPHRPY、WPRHPY、WRPHPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 20.90%，低于母本的 42.13%", "几何阻断占有率 21.21%，低于母本的 68.61%", "结合样状态占比 18.51%，低于母本的 64.07%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "WPHPLY": { "sequence": "WPHPLY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.32412749186039863, "blockade": 0.47161135545781685, "bound_like": 0.44822071171531386, "late_bound_like": 0.10594702648675662, "delta_coverage_pp": -9.717541554806653, "delta_blockade_pp": -21.451419432227116, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "HWPHPY", "KWPHPY", "RWPHPY", "WPHKPY", "WPHRPY" ], "reasons": [ "本组 WPHPY、HWPHPY、KWPHPY、RWPHPY、WPHKPY、WPHRPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 32.41%，低于母本的 42.13%", "几何阻断占有率 47.16%，低于母本的 68.61%", "结合样状态占比 44.82%，低于母本的 64.07%", "40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 10.59%，低于全程的 44.82%，需要回看时间变化" ] }, "WPHRPY": { "sequence": "WPHRPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.38211858113897296, "blockade": 0.5635745701719312, "bound_like": 0.549780087964814, "late_bound_like": 0.8595702148925537, "delta_coverage_pp": -3.91843262694922, "delta_blockade_pp": -12.255097960815675, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns" ], "dominated_by": [ "WPHPY", "RWPHPY" ], "reasons": [ "本组 WPHPY、RWPHPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 38.21%，低于母本的 42.13%", "几何阻断占有率 56.36%，低于母本的 68.61%", "结合样状态占比 54.98%，低于母本的 64.07%", "0-20 ns、20-40 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "WPRHPY": { "sequence": "WPRHPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.290483806477409, "blockade": 0.4460215913634546, "bound_like": 0.4218312674930028, "late_bound_like": 0.39980009995002497, "delta_coverage_pp": -13.081910093105614, "delta_blockade_pp": -24.01039584166334, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "HWPHPY", "KWPHPY", "RWPHPY", "WPHKPY", "WPHPLY", "WPHRPY" ], "reasons": [ "本组 WPHPY、HWPHPY、KWPHPY、RWPHPY、WPHKPY、WPHPLY、WPHRPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 29.05%，低于母本的 42.13%", "几何阻断占有率 44.60%，低于母本的 68.61%", "结合样状态占比 42.18%，低于母本的 64.07%", "20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 39.98%，低于全程的 42.18%，需要回看时间变化" ] }, "WRPHPY": { "sequence": "WRPHPY", "parent_seed": "WPHPY", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.24063231850117092, "blockade": 0.2994802079168333, "bound_like": 0.19712115153938425, "late_bound_like": 0.05897051474262868, "delta_coverage_pp": -18.067058890729424, "delta_blockade_pp": -38.66453418632547, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "WPHPY", "HWPHPY", "KWPHPY", "RWPHPY", "WNPHPY", "WPHKPY", "WPHPLY", "WPHRPY", "WPRHPY" ], "reasons": [ "本组 WPHPY、HWPHPY、KWPHPY、RWPHPY、WNPHPY、WPHKPY、WPHPLY、WPHRPY、WPRHPY 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 24.06%，低于母本的 42.13%", "几何阻断占有率 29.95%，低于母本的 68.61%", "结合样状态占比 19.71%，低于母本的 64.07%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 5.90%，低于全程的 19.71%，需要回看时间变化" ] }, "EWWFR": { "sequence": "EWWFR", "parent_seed": "EWWFR", "level": "parent", "label": "原五肽", "color": "#2474d2" }, "EWHWFR": { "sequence": "EWHWFR", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.3039070086251214, "blockade": 0.5597760895641744, "bound_like": 0.5005997600959616, "late_bound_like": 0.9725137431284357, "delta_coverage_pp": 3.4586165533786515, "delta_blockade_pp": 2.019192323070773, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns" ], "dominated_by": [ "EWKWFR", "EWRWFR", "EWWAFR", "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRR", "EWWYFR" ], "reasons": [ "本组 EWKWFR、EWRWFR、EWWAFR、EWWFAR、EWWFKR、EWWFRL、EWWFRR、EWWYFR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "0-20 ns、20-40 ns、40-60 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "EWKWFR": { "sequence": "EWKWFR", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.361298337807734, "blockade": 0.6545381847261096, "bound_like": 0.5613754498200719, "late_bound_like": 0.7586206896551724, "delta_coverage_pp": 9.197749471639916, "delta_blockade_pp": 11.495401839264296, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns" ], "dominated_by": [ "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRR" ], "reasons": [ "本组 EWWFAR、EWWFKR、EWWFRL、EWWFRR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "0-20 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "EWRWFR": { "sequence": "EWRWFR", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.31780145084823214, "blockade": 0.7325069972011196, "bound_like": 0.6409436225509796, "late_bound_like": 0.7711144427786107, "delta_coverage_pp": 4.848060775689728, "delta_blockade_pp": 19.292283086765295, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns" ], "dominated_by": [ "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRR" ], "reasons": [ "本组 EWWFAR、EWWFKR、EWWFRL、EWWFRR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "0-20 ns、20-40 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "EWWAFR": { "sequence": "EWWAFR", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.313446050151368, "blockade": 0.7648940423830468, "bound_like": 0.45081967213114754, "late_bound_like": 0.42128935532233885, "delta_coverage_pp": 4.412520706003314, "delta_blockade_pp": 22.53098760495802, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": false }, "failed_windows": [], "dominated_by": [ "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRR" ], "reasons": [ "本组 EWWFAR、EWWFKR、EWWFRL、EWWFRR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "后40 ns的结合样状态占比为 42.13%，低于全程的 45.08%，需要回看时间变化" ] }, "EWWFAR": { "sequence": "EWWFAR", "parent_seed": "EWWFR", "level": "priority", "label": "优先补充验证", "color": "#0f766e", "coverage": 0.5256183240989318, "blockade": 0.999000399840064, "bound_like": 0.9802079168332667, "late_bound_like": 0.9910044977511244, "delta_coverage_pp": 25.6297481007597, "delta_blockade_pp": 45.94162335065973, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": true }, "failed_windows": [], "dominated_by": [], "reasons": [ "全程覆盖率与几何阻断指标均不低于母本，五个时段也都达到母本的整体水平", "后40 ns的结合样状态占比为 99.10%，全程为 98.02%；这只是数值对照，不代表差异显著" ] }, "EWWFKR": { "sequence": "EWWFKR", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.44302279088364643, "blockade": 0.7766893242702919, "bound_like": 0.7676929228308677, "late_bound_like": 0.46776611694152925, "delta_coverage_pp": 17.370194779231156, "delta_blockade_pp": 23.71051579368253, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "60-80ns", "80-100ns" ], "dominated_by": [ "EWWFAR", "EWWFRL", "EWWFRR" ], "reasons": [ "本组 EWWFAR、EWWFRL、EWWFRR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 46.78%，低于全程的 76.77%，需要回看时间变化" ] }, "EWWFPR": { "sequence": "EWWFPR", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.22790883646541382, "blockade": 0.26489404238304676, "bound_like": 0.18572570971611355, "late_bound_like": 0.047976011994003, "delta_coverage_pp": -4.141200662592103, "delta_blockade_pp": -27.469012395041986, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "EWWFR", "EWHWFR", "EWKWFR", "EWRWFR", "EWWAFR", "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRQ", "EWWFRR", "EWWFRS", "EWWYFR" ], "reasons": [ "本组 EWWFR、EWHWFR、EWKWFR、EWRWFR、EWWAFR、EWWFAR、EWWFKR、EWWFRL、EWWFRQ、EWWFRR、EWWFRS、EWWYFR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 22.79%，低于母本的 26.93%", "几何阻断占有率 26.49%，低于母本的 53.96%", "结合样状态占比 18.57%，低于母本的 30.93%", "20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 4.80%，低于全程的 18.57%，需要回看时间变化" ] }, "EWWFRL": { "sequence": "EWWFRL", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.47796595647455303, "blockade": 0.8512594962015194, "bound_like": 0.8148740503798481, "late_bound_like": 0.591704147926037, "delta_coverage_pp": 20.86451133832182, "delta_blockade_pp": 31.16753298680528, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "80-100ns" ], "dominated_by": [ "EWWFAR", "EWWFRR" ], "reasons": [ "本组 EWWFAR、EWWFRR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 59.17%，低于全程的 81.49%，需要回看时间变化" ] }, "EWWFRQ": { "sequence": "EWWFRQ", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.2865425258468041, "blockade": 0.3548580567772891, "bound_like": 0.3140743702518992, "late_bound_like": 0.24187906046976512, "delta_coverage_pp": 1.7221682755469259, "delta_blockade_pp": -18.472610955617753, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": false, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "EWHWFR", "EWKWFR", "EWRWFR", "EWWAFR", "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRR", "EWWYFR" ], "reasons": [ "本组 EWHWFR、EWKWFR、EWRWFR、EWWAFR、EWWFAR、EWWFKR、EWWFRL、EWWFRR、EWWYFR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "几何阻断占有率 35.49%，低于母本的 53.96%", "20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 24.19%，低于全程的 31.41%，需要回看时间变化" ] }, "EWWFRR": { "sequence": "EWWFRR", "parent_seed": "EWWFR", "level": "caution", "label": "有优势，也有疑点", "color": "#d97706", "coverage": 0.5410835665733706, "blockade": 0.936625349860056, "bound_like": 0.8676529388244703, "late_bound_like": 0.6761619190404797, "delta_coverage_pp": 27.17627234820358, "delta_blockade_pp": 39.70411835265894, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": false }, "failed_windows": [], "dominated_by": [], "reasons": [ "后40 ns的结合样状态占比为 67.62%，低于全程的 86.77%，需要回看时间变化" ] }, "EWWFRS": { "sequence": "EWWFRS", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.26339464214314273, "blockade": 0.5017992802878849, "bound_like": 0.40103958416633345, "late_bound_like": 0.026986506746626688, "delta_coverage_pp": -0.5926200948192129, "delta_blockade_pp": -3.7784886045581723, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "EWWFR", "EWHWFR", "EWKWFR", "EWRWFR", "EWWAFR", "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRR", "EWWYFR" ], "reasons": [ "本组 EWWFR、EWHWFR、EWKWFR、EWRWFR、EWWAFR、EWWFAR、EWWFKR、EWWFRL、EWWFRR、EWWYFR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 26.34%，低于母本的 26.93%", "几何阻断占有率 50.18%，低于母本的 53.96%", "40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 2.70%，低于全程的 40.10%，需要回看时间变化" ] }, "EWWYFR": { "sequence": "EWWYFR", "parent_seed": "EWWFR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.3141457702633232, "blockade": 0.5683726509396242, "bound_like": 0.3916433426629348, "late_bound_like": 0.5067466266866567, "delta_coverage_pp": 4.4824927171988325, "delta_blockade_pp": 2.878848460615757, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "20-40ns", "40-60ns", "60-80ns" ], "dominated_by": [ "EWKWFR", "EWRWFR", "EWWFAR", "EWWFKR", "EWWFRL", "EWWFRR" ], "reasons": [ "本组 EWKWFR、EWRWFR、EWWFAR、EWWFKR、EWWFRL、EWWFRR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "20-40 ns、40-60 ns、60-80 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "RNWIR": { "sequence": "RNWIR", "parent_seed": "RNWIR", "level": "parent", "label": "原五肽", "color": "#2474d2" }, "RFNWIR": { "sequence": "RFNWIR", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.3383932141429143, "blockade": 0.5343862455017993, "bound_like": 0.4998000799680128, "late_bound_like": 0.6931534232883558, "delta_coverage_pp": 13.738790198206436, "delta_blockade_pp": 26.089564174330267, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns" ], "dominated_by": [ "RNIWIR", "RNWIRT", "RNWIRV", "RNWWIR", "RYNWIR", "TRNWIR", "VRNWIR", "YRNWIR" ], "reasons": [ "本组 RNIWIR、RNWIRT、RNWIRV、RNWWIR、RYNWIR、TRNWIR、VRNWIR、YRNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "0-20 ns、20-40 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "RNDWIR": { "sequence": "RNDWIR", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.3358228137316501, "blockade": 0.6005597760895641, "bound_like": 0.5219912035185925, "late_bound_like": 0.18640679660169915, "delta_coverage_pp": 13.481750157080018, "delta_blockade_pp": 32.70691723310675, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "80-100ns" ], "dominated_by": [ "RNIWIR", "RNVWIR", "RNWIRT", "RNWIRV", "RNWWIR", "RYNWIR", "TRNWIR", "VRNWIR", "YRNWIR" ], "reasons": [ "本组 RNIWIR、RNVWIR、RNWIRT、RNWIRV、RNWWIR、RYNWIR、TRNWIR、VRNWIR、YRNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 18.64%，低于全程的 52.20%，需要回看时间变化" ] }, "RNIWIR": { "sequence": "RNIWIR", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.3578996972639516, "blockade": 0.6051579368252699, "bound_like": 0.5509796081567373, "late_bound_like": 0.760119940029985, "delta_coverage_pp": 15.689438510310167, "delta_blockade_pp": 33.16673330667733, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "20-40ns" ], "dominated_by": [ "RNWIRT", "RNWIRV", "RNWWIR", "RYNWIR", "TRNWIR", "VRNWIR", "YRNWIR" ], "reasons": [ "本组 RNWIRT、RNWIRV、RNWWIR、RYNWIR、TRNWIR、VRNWIR、YRNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "20-40 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "RNKWIR": { "sequence": "RNKWIR", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.35675729708116755, "blockade": 0.49540183926429426, "bound_like": 0.4306277489004398, "late_bound_like": 0.5487256371814093, "delta_coverage_pp": 15.575198492031761, "delta_blockade_pp": 22.191123550579768, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns" ], "dominated_by": [ "RNIWIR", "RNWIRT", "RNWIRV", "RNWWIR", "RYNWIR", "TRNWIR", "VRNWIR", "YRNWIR" ], "reasons": [ "本组 RNIWIR、RNWIRT、RNWIRV、RNWWIR、RYNWIR、TRNWIR、VRNWIR、YRNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "0-20 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "RNVWIR": { "sequence": "RNVWIR", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.33829325412692063, "blockade": 0.638344662135146, "bound_like": 0.5385845661735306, "late_bound_like": 0.8605697151424287, "delta_coverage_pp": 13.728794196607069, "delta_blockade_pp": 36.485405837664935, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns" ], "dominated_by": [ "RNWIRT", "RNWIRV", "RNWWIR", "RYNWIR", "TRNWIR", "VRNWIR", "YRNWIR" ], "reasons": [ "本组 RNWIRT、RNWIRV、RNWWIR、RYNWIR、TRNWIR、VRNWIR、YRNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "0-20 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "RNWIRT": { "sequence": "RNWIRT", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.38301822128291535, "blockade": 0.8648540583766493, "bound_like": 0.8198720511795282, "late_bound_like": 0.9205397301349325, "delta_coverage_pp": 18.20129091220654, "delta_blockade_pp": 59.136345461815274, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": true }, "failed_windows": [], "dominated_by": [ "RYNWIR" ], "reasons": [ "本组 RYNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先" ] }, "RNWIRV": { "sequence": "RNWIRV", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.40676586508253837, "blockade": 0.790483806477409, "bound_like": 0.7455017992802879, "late_bound_like": 0.6191904047976012, "delta_coverage_pp": 20.576055292168842, "delta_blockade_pp": 51.69932027189124, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": false }, "failed_windows": [], "dominated_by": [ "RNWWIR", "RYNWIR" ], "reasons": [ "本组 RNWWIR、RYNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "后40 ns的结合样状态占比为 61.92%，低于全程的 74.55%，需要回看时间变化" ] }, "RNWWIR": { "sequence": "RNWWIR", "parent_seed": "RNWIR", "level": "priority", "label": "优先补充验证", "color": "#0f766e", "coverage": 0.500642600102816, "blockade": 0.7956817273090764, "bound_like": 0.7762894842063175, "late_bound_like": 0.7786106946526736, "delta_coverage_pp": 29.96372879419661, "delta_blockade_pp": 52.21911235505799, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": true }, "failed_windows": [], "dominated_by": [], "reasons": [ "全程覆盖率与几何阻断指标均不低于母本，五个时段也都达到母本的整体水平", "后40 ns的结合样状态占比为 77.86%，全程为 77.63%；这只是数值对照，不代表差异显著" ] }, "RYNWIR": { "sequence": "RYNWIR", "parent_seed": "RNWIR", "level": "priority", "label": "优先补充验证", "color": "#0f766e", "coverage": 0.4516907522705204, "blockade": 0.9614154338264694, "bound_like": 0.919032387045182, "late_bound_like": 0.9910044977511244, "delta_coverage_pp": 25.06854401096705, "delta_blockade_pp": 68.79248300679728, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": true }, "failed_windows": [], "dominated_by": [], "reasons": [ "全程覆盖率与几何阻断指标均不低于母本，五个时段也都达到母本的整体水平", "后40 ns的结合样状态占比为 99.10%，全程为 91.90%；这只是数值对照，不代表差异显著" ] }, "TRNWIR": { "sequence": "TRNWIR", "parent_seed": "RNWIR", "level": "caution", "label": "有优势，也有疑点", "color": "#d97706", "coverage": 0.50142800022848, "blockade": 0.7323070771691323, "bound_like": 0.7315073970411835, "late_bound_like": 0.6686656671664168, "delta_coverage_pp": 30.042268806763005, "delta_blockade_pp": 45.88164734106358, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": false }, "failed_windows": [], "dominated_by": [], "reasons": [ "后40 ns的结合样状态占比为 66.87%，低于全程的 73.15%，需要回看时间变化" ] }, "VRNWIR": { "sequence": "VRNWIR", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.38668818187010906, "blockade": 0.7696921231507396, "bound_like": 0.7003198720511795, "late_bound_like": 0.6771614192903548, "delta_coverage_pp": 18.56828697092591, "delta_blockade_pp": 49.62015193922431, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": false }, "failed_windows": [], "dominated_by": [ "RNWIRV", "RNWWIR", "RYNWIR" ], "reasons": [ "本组 RNWIRV、RNWWIR、RYNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "后40 ns的结合样状态占比为 67.72%，低于全程的 70.03%，需要回看时间变化" ] }, "YRNWIR": { "sequence": "YRNWIR", "parent_seed": "RNWIR", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.35847089735534354, "blockade": 0.6973210715713715, "bound_like": 0.6429428228708517, "late_bound_like": 0.6756621689155422, "delta_coverage_pp": 15.74655851944936, "delta_blockade_pp": 42.38304678128749, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": true, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": true, "late_bound_not_below_own_full": true }, "failed_windows": [], "dominated_by": [ "RNWIRT", "RNWIRV", "RNWWIR", "RYNWIR", "TRNWIR", "VRNWIR" ], "reasons": [ "本组 RNWIRT、RNWIRV、RNWWIR、RYNWIR、TRNWIR、VRNWIR 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先" ] }, "IHWRW": { "sequence": "IHWRW", "parent_seed": "IHWRW", "level": "parent", "label": "原五肽", "color": "#2474d2" }, "FIHWRW": { "sequence": "FIHWRW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.3587850574056091, "blockade": 0.546781287485006, "bound_like": 0.4808076769292283, "late_bound_like": 0.22438780609695153, "delta_coverage_pp": -28.70851659336266, "delta_blockade_pp": -43.86245501799281, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "IHFWRW", "IHKWRW", "IHWKRW", "IHWRIW", "IHWRPW", "IKHWRW", "IRHWRW" ], "reasons": [ "本组 IHWRW、IHFWRW、IHKWRW、IHWKRW、IHWRIW、IHWRPW、IKHWRW、IRHWRW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 35.88%，低于母本的 64.59%", "几何阻断占有率 54.68%，低于母本的 98.54%", "结合样状态占比 48.08%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 22.44%，低于全程的 48.08%，需要回看时间变化" ] }, "IHFWRW": { "sequence": "IHFWRW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.5005854800936769, "blockade": 0.846061575369852, "bound_like": 0.8398640543782487, "late_bound_like": 0.6256871564217891, "delta_coverage_pp": -14.528474324555884, "delta_blockade_pp": -13.934426229508201, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "IHWKRW", "IHWRIW", "IHWRPW" ], "reasons": [ "本组 IHWRW、IHWKRW、IHWRIW、IHWRPW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 50.06%，低于母本的 64.59%", "几何阻断占有率 84.61%，低于母本的 98.54%", "结合样状态占比 83.99%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 62.57%，低于全程的 83.99%，需要回看时间变化" ] }, "IHKWRW": { "sequence": "IHKWRW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.504426800708288, "blockade": 0.8280687724910036, "bound_like": 0.8278688524590164, "late_bound_like": 0.8105947026486756, "delta_coverage_pp": -14.144342263094767, "delta_blockade_pp": -15.733706517393042, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "IHWKRW", "IHWRIW", "IHWRPW" ], "reasons": [ "本组 IHWRW、IHWKRW、IHWRIW、IHWRPW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 50.44%，低于母本的 64.59%", "几何阻断占有率 82.81%，低于母本的 98.54%", "结合样状态占比 82.79%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 81.06%，低于全程的 82.79%，需要回看时间变化" ] }, "IHWFRW": { "sequence": "IHWFRW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.20961615353858457, "blockade": 0.2840863654538185, "bound_like": 0.25069972011195524, "late_bound_like": 0.1294352823588206, "delta_coverage_pp": -43.625406980065115, "delta_blockade_pp": -70.13194722111156, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "FIHWRW", "IHFWRW", "IHKWRW", "IHWKRW", "IHWRAW", "IHWRIW", "IHWRPW", "IHWRWD", "IHWRWN", "IKHWRW", "IRHWRW" ], "reasons": [ "本组 IHWRW、FIHWRW、IHFWRW、IHKWRW、IHWKRW、IHWRAW、IHWRIW、IHWRPW、IHWRWD、IHWRWN、IKHWRW、IRHWRW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 20.96%，低于母本的 64.59%", "几何阻断占有率 28.41%，低于母本的 98.54%", "结合样状态占比 25.07%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 12.94%，低于全程的 25.07%，需要回看时间变化" ] }, "IHWKRW": { "sequence": "IHWKRW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.6432712629234021, "blockade": 0.8890443822471011, "bound_like": 0.8858456617353059, "late_bound_like": 0.993503248375812, "delta_coverage_pp": -0.2598960415833629, "delta_blockade_pp": -9.636145541783293, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns" ], "dominated_by": [ "IHWRW" ], "reasons": [ "本组 IHWRW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 64.33%，低于母本的 64.59%", "几何阻断占有率 88.90%，低于母本的 98.54%", "结合样状态占比 88.58%，低于母本的 98.54%", "0-20 ns、20-40 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "IHWRAW": { "sequence": "IHWRAW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.25272748043639687, "blockade": 0.37784886045581767, "bound_like": 0.3558576569372251, "late_bound_like": 0.19790104947526238, "delta_coverage_pp": -39.31427429028388, "delta_blockade_pp": -60.75569772091164, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "FIHWRW", "IHFWRW", "IHKWRW", "IHWKRW", "IHWRIW", "IHWRPW", "IHWRWD", "IHWRWN", "IKHWRW", "IRHWRW" ], "reasons": [ "本组 IHWRW、FIHWRW、IHFWRW、IHKWRW、IHWKRW、IHWRIW、IHWRPW、IHWRWD、IHWRWN、IKHWRW、IRHWRW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 25.27%，低于母本的 64.59%", "几何阻断占有率 37.78%，低于母本的 98.54%", "结合样状态占比 35.59%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 19.79%，低于全程的 35.59%，需要回看时间变化" ] }, "IHWRIW": { "sequence": "IHWRIW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.5678300108528018, "blockade": 0.9432227109156337, "bound_like": 0.9374250299880048, "late_bound_like": 0.8875562218890555, "delta_coverage_pp": -7.804021248643389, "delta_blockade_pp": -4.218312674930036, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "IHWRPW" ], "reasons": [ "本组 IHWRW、IHWRPW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 56.78%，低于母本的 64.59%", "几何阻断占有率 94.32%，低于母本的 98.54%", "结合样状态占比 93.74%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 88.76%，低于全程的 93.74%，需要回看时间变化" ] }, "IHWRPW": { "sequence": "IHWRPW", "parent_seed": "IHWRW", "level": "caution", "label": "有优势，也有疑点", "color": "#d97706", "coverage": 0.5883789341406295, "blockade": 0.9914034386245502, "bound_like": 0.9914034386245502, "late_bound_like": 0.9850074962518741, "delta_coverage_pp": -5.749128919860624, "delta_blockade_pp": 0.5997600959616101, "tests": { "qc_pass": true, "primary_frontier": true, "coverage_not_below_parent": false, "blockade_not_below_parent": true, "bound_not_below_parent": true, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "80-100ns" ], "dominated_by": [], "reasons": [ "覆盖率 58.84%，低于母本的 64.59%", "0-20 ns、20-40 ns、40-60 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 98.50%，低于全程的 99.14%，需要回看时间变化" ] }, "IHWRWD": { "sequence": "IHWRWD", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.30686296909807503, "blockade": 0.4026389444222311, "bound_like": 0.2932826869252299, "late_bound_like": 0.13243378310844578, "delta_coverage_pp": -33.90072542411607, "delta_blockade_pp": -58.2766893242703, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "FIHWRW", "IHFWRW", "IHKWRW", "IHWKRW", "IHWRIW", "IHWRPW", "IKHWRW", "IRHWRW" ], "reasons": [ "本组 IHWRW、FIHWRW、IHFWRW、IHKWRW、IHWKRW、IHWRIW、IHWRPW、IKHWRW、IRHWRW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 30.69%，低于母本的 64.59%", "几何阻断占有率 40.26%，低于母本的 98.54%", "结合样状态占比 29.33%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 13.24%，低于全程的 29.33%，需要回看时间变化" ] }, "IHWRWN": { "sequence": "IHWRWN", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.28535728565716567, "blockade": 0.4226309476209516, "bound_like": 0.3480607756897241, "late_bound_like": 0.01699150424787606, "delta_coverage_pp": -36.051293768207, "delta_blockade_pp": -56.27748900439824, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "FIHWRW", "IHFWRW", "IHKWRW", "IHWKRW", "IHWRIW", "IHWRPW", "IKHWRW", "IRHWRW" ], "reasons": [ "本组 IHWRW、FIHWRW、IHFWRW、IHKWRW、IHWKRW、IHWRIW、IHWRPW、IKHWRW、IRHWRW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 28.54%，低于母本的 64.59%", "几何阻断占有率 42.26%，低于母本的 98.54%", "结合样状态占比 34.81%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 1.70%，低于全程的 34.81%，需要回看时间变化" ] }, "IKHWRW": { "sequence": "IKHWRW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.4822499571599931, "blockade": 0.7620951619352259, "bound_like": 0.7181127548980408, "late_bound_like": 0.8490754622688655, "delta_coverage_pp": -16.362026617924265, "delta_blockade_pp": -22.33106757297082, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": true }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "IHFWRW", "IHKWRW", "IHWKRW", "IHWRIW", "IHWRPW" ], "reasons": [ "本组 IHWRW、IHFWRW、IHKWRW、IHWKRW、IHWRIW、IHWRPW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 48.22%，低于母本的 64.59%", "几何阻断占有率 76.21%，低于母本的 98.54%", "结合样状态占比 71.81%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平" ] }, "IRHWRW": { "sequence": "IRHWRW", "parent_seed": "IHWRW", "level": "unmarked", "label": "暂不优先", "color": "#94a3b8", "coverage": 0.4811932369909179, "blockade": 0.8424630147940824, "bound_like": 0.7956817273090764, "late_bound_like": 0.7286356821589205, "delta_coverage_pp": -16.46769863483178, "delta_blockade_pp": -14.294282287085169, "tests": { "qc_pass": true, "primary_frontier": false, "coverage_not_below_parent": false, "blockade_not_below_parent": false, "bound_not_below_parent": false, "all_blocks_above_parent_full_baseline": false, "late_bound_not_below_own_full": false }, "failed_windows": [ "0-20ns", "20-40ns", "40-60ns", "60-80ns", "80-100ns" ], "dominated_by": [ "IHWRW", "IHFWRW", "IHWKRW", "IHWRIW", "IHWRPW" ], "reasons": [ "本组 IHWRW、IHFWRW、IHWKRW、IHWRIW、IHWRPW 的覆盖率与几何阻断指标均不低、至少一项更高，因此这条暂不优先", "覆盖率 48.12%，低于母本的 64.59%", "几何阻断占有率 84.25%，低于母本的 98.54%", "结合样状态占比 79.57%，低于母本的 98.54%", "0-20 ns、20-40 ns、40-60 ns、60-80 ns、80-100 ns没有同时达到母本100 ns的覆盖率和几何阻断水平", "后40 ns的结合样状态占比为 72.86%，低于全程的 79.57%，需要回看时间变化" ] } }, "validation_context": { "source_report": "schrodinger_dual_model/epitope_control/md_100ns/analysis/correlation_analysis/CORRELATION_REPORT.md", "copy": "references/ISOLATED_VALIDATION_REPORT.md", "sha256": "a4b8d201c6d5496cc1bd23c5b25376612c319e5496929fd26fa98d5880b70e5e" } }